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TGF-β in human milk is associated with wheeze in infancy.

TGF-β in human milk is associated with wheeze in infancy.









No. Divisions/Titles for Abstract Details

1 Abstract Title TGF-β in human milk is associated with wheeze in infancy.


2 Abstract Source Journal of Allergy and Clinical Immunology, 112, 723-728.


3 Abstract Author(s) Oddy, W. H., Halonen, M., Martinez, F. D., Lohman, I. C., Stern, D. A., Kurzius-Spencer, M., Guerra, S. & Wright, A. L.


4 Article Affiliation a Department of Nutrition, Dietetics, and Food Science, Curtin University of Technology, Perth, Australia
b Centre for Child Health Research, University of Western Australia, Perth, Australia
c Arizona Respiratory Center, University of Arizona, Tuscon, Ariz, USA.


5 Abstract Background
Cytokines secreted in human milk might play important roles in newborn health and in the development of infant immune responses. We investigated the relationship of the concentration and dose of cytokines in human milk to infant wheeze at 1 year of age.
Objective
Our objective was to test whether the cytokines in milk could account for some of the apparent protective effect of breast-feeding against wheeze in the first year of life.
Methods
Data on breast-feeding and infant wheeze were collected prospectively from birth to 1 year from 243 mothers participating in the Infant Immune Study in Tucson, Arizona. Breast milk samples obtained at a mean age of 11 days postpartum were assayed by means of ELISA for concentrations of TGF-β1, IL-10, TNF-α, and the soluble form of CD14. The dose of each cytokine was assessed for a relationship with wheeze in bivariate and logistic regression analyses.
Results
Increasing duration of breast-feeding was significantly associated with a decreased prevalence of wheeze (P = .039). There was wide variability in levels of each cytokine in milk, as well as variability between women in the amount of each cytokine produced. There was a significant inverse association between the dose of TGF-β1 received through milk with the percentage of wheeze (P = .017), and the relationship was linear (P = .006). None of the other cytokines showed a linear relationship with wheeze. In multivariate analyses the risk of wheeze was significantly decreased (odds ratio, 0.22; 95% CI 0.05-0.89; P = .034) with increasing TGF-β1 dose (long breast-feeding and medium-high TGF-β1 level compared with short breast-feeding and low TGF-β.
Conclusion
This analysis shows that the dose of TGF-β1 received from milk has a significant relationship with infant wheeze, which might account for at least some of the protective effect of breast-feeding against wheeze.


6 Summary This analysis shows that the dose of TGF-β1 received from milk has a significant relationship with infant wheeze, which might account for at least some of the protective effect of breast-feeding against wheeze.


7 Article Published Date October 2003.


8 Study Type Clinical.


9 Substances Colostrum.( Colostrum contains TGF-β1 https://goo.gl/5uLBbd)


10 Diseases wheeze.


11 Pharmacological Actions Protective effect of TGF-β1 against infant wheeze.


12 Link https://goo.gl/W3aKsL








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