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Relaxant effect of essential oil of Melissa officinalis and citral on rat ileum contractions.

Relaxant effect of essential oil of Melissa officinalis and citral on rat ileum contractions.










No.Divisions/Titles for AbstractDetails

1Abstract TitleRelaxant effect of essential oil of Melissa officinalis and citral on rat ileum contractions.


2Abstract SourceFitoterapia, 74, 445-452.


3Abstract Author(s)Sadraei, H., Ghannadi, A. & Malekshahi, K. 


4Article AffiliationDepartment of Pharmacology, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran.


5AbstractThe relaxant (a drug used to promote relaxation or reduce tension) effect of the essential oil of Melissa officinalis and its main component, citral, on rat isolated ileum (The ileum is about 3.5 metres (11.5 feet) long (or about three-fifths the length of the small intestine) and extends from the jejunum (the middle section of the small intestine) to the ileocecal valve, which empties into the colon (large intestine)) contractions was evaluated. M. officinalis essential oil (MOEO) inhibited the response to KCl (80 mM), ACh (320 nM) and 5-HT (1.28 μM) in a concentration-dependent manner with a IC50 of approximately 20 ng/ml. Citral also had a concentration-dependent inhibitory effect on contraction of rat ileum with IC50s comparable to that of MOEO.


6SummaryIn conclusion, this study showed that M. officinalis essential oil and its main component, citral, possess a significant inhibition effect on ileum contractions. Therefore, it seems to be a useful herbal medicine for the treatment of gastrointestinal spasms.The 5-HT contraction is mediated by the release of ACh from the cholinergic neurone as well as activation of serotonergic receptors on the smooth muscles of ileum . M. officinalis essential oil and citral relax the ileum contraction due to depolarisation (KCl) and inhibition of agonist effect on muscarinic or serotonergic receptors. This inhibitory effect may indicate a more general inhibitory mechanism of action, which includes a significant inhibition effect on Ca2q ion channels . In addition, by means of electrophysiological technique, it has been shown that peppermint oil can block L-type Ca2q channels in the ileum.


7Article Published DateJuly 2003.

8Study TypeInvitro.

9SubstancesMelissa.

10DiseasesIBS.

11Pharmacological ActionsTreatment of IBS.

12Linkhttps://goo.gl/DSJxE








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