Physiology and Endocrine Changes Underlying Human Lactogenesis II.


No.	Divisions/Titles for Abstract	Details
1	Abstract Title	Physiology and Endocrine Changes Underlying Human Lactogenesis II.
2	Abstract Source	The Journal of nutrition, 131, 3005S-3008S.
3	Abstract Author(s)	Neville, M. C. & Morton, J.
4	Article Affiliation	*Department of Physiology, University of Colorado Health Sciences Center, Denver CO 80262 and Stanford University School of Medicine, Palo Alto Medical Foundation, Palo Alto, CA 94028.
5	Abstract	Lactogenesis stage II, the onset of copious milk secretion, takes place during the first 4 d postpartum in women and involves a carefully programmed set of changes in milk composition and volume. The evidence is summarized that progesterone withdrawal at parturition provides the trigger for lactogenesis in the presence of high plasma concentrations of prolactin and adequate plasma concentrations of cortisol. Although the process is generally robust, delayed lactogenesis does occur with stressful deliveries and in poorly controlled diabetes. Failure of early removal of colostrum from the breast is associated with high milk sodium and poor prognosis for successful lactation in many women. We speculate that this problem may result from accumulation of a substance in the mammary alveolus that inhibits lactogenesis, even in the face of appropriate hormonal changes after parturition.
6	Summary	Lactogenesis stage II, the onset of copious milk secretion, takes place during the first 4 d postpartum in women and involves a carefully programmed set of changes in milk composition and volume . In this short article we discuss the developmental switch represented by lactogenesis stage II. The changes in milk composition and volume attendant on this switch in women are outlined first, followed by a discussion of the role of hormones in its initiation. Finally, the scanty findings concerning the role of milk removal and a hypothesis for a role of an inhibitor of lactogenesis are presented as a guide to future research.
7	Article Published Date	Nov-2001.
8	Study Type	Review.
9	Substances	Colostrum.
10	Diseases	lactogenesis.
11	Pharmacological Actions	factors effecting lactogenesis.
12	Link	https://goo.gl/ofrUHH