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Olive (olea europaea l.) leaf extract elicits antinociceptive activity, potentiates morphine analgesia and suppresses morphine hyperalgesia in rats.

Olive (olea europaea l.) leaf extract elicits antinociceptive activity, potentiates morphine analgesia and suppresses morphine hyperalgesia in rats.









No. Divisions/Titles for Abstract Details

1 Abstract Title Olive (olea europaea l.) leaf extract elicits antinociceptive activity, potentiates morphine analgesia and suppresses morphine hyperalgesia in rats.


2 Abstract Source Journal of Ethnopharmacology, 132, 200-205.


3 Abstract Author(s) Esmaeili-Mahani, S., Rezaeezadeh-Roukerd, M., Esmaeilpour, K., Abbasnejad, M., Rasoulian, B., Sheibani, V., Kaeidi, A. & Hajializadeh, Z.


4 Article Affiliation Department of Biology, Faculty of Sciences, Shahid Bahonar University of Kerman, Kerman, Iran.


5 Abstract Aim of the study: Olive (Olea europaea) leaves are used as anti-rheumatic, anti-inflammatory, antinociceptive, antipyretic, vasodilatory, hypotensive, antidiuretic and hypoglycemic agents in traditional medicine. Recently, it has been shown that olive leaf extract (OLE) has calcium channel blocker property; however, its influences on nociceptive threshold and morphine effects have not yet been clarified. Materials and methods: All experiments were carried out on male Wistar rats. The tail-flick, hot-plate and formalin tests were used to assess the effect of OLE on nociceptive threshold. To determine the effect of OLE on analgesic and hyperalgesic effects of morphine, OLE (6, 12 and 25 mg/kg i.p.) that had no significant nociceptive effect, was injected concomitant with morphine (5 mg/kg and 1 g/kg i.p., respectively). The tail-flick test was used to assess the effect of OLE on anti- and pro-nociceptive effects of morphine. Results: The data showed that OLE (50–200 mg/kg i.p.) could produce dose-dependent analgesic effect on tail-flick and hot-plate tests. Administration of 200 mg/kg OLE (i.p.) caused significant decrease in pain responses in the first and the second phases of formalin test. In addition, OLE could potentiate the antinociceptive effect of 5 mg/kg morphine and block low-dose morphine-induced hyperalgesia. Conclusion: Our results indicate that olive leaf extract has analgesic property in several models of pain and useful influence on morphine analgesia in rats. Therefore, it can be used for the treatment and/or management of painful conditions.


6 Summary -


7 Article Published Date
28 October 2010.


8 Study Type Invivo.


9 Substances Olive leaf.


10 Diseases Algesia.


11 Pharmacological Actions Analgesic.


12 Link https://goo.gl/Nq9hhX








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