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Olive leaf extracts are a natural source of advanced glycation end product inhibitors.

Olive leaf extracts are a natural source of advanced glycation end product inhibitors.









No. Divisions/Titles for Abstract Details

1 Abstract Title Olive leaf extracts are a natural source of advanced glycation end product inhibitors.


2 Abstract Source Journal of medicinal food, 16, 817-822.


3 Abstract Author(s) Kontogianni, V. G., Charisiadis, P., Margianni, E., Lamari, F. N., Gerothanassis, I. P. & Tzakos, A. G.


4 Article Affiliation Department of Chemistry, University of Ioannina, Ioannina, Greece.


5 Abstract Advanced glycation end products (AGEs), which are readily formed and accumulated with sustained hyperglycemia, contribute to the development of diabetic complications. As a consequence, inhibition of AGE formation constitutes an attractive therapeutic/preventive target. In the current study, we explored the phytochemical composition and the in vitro effect of two different olive leaf extracts (an aqueous and a methanolic) on AGE formation. The methanolic olive leaf extract inhibited fluorescent AGE formation in a bovine serum albumin (BSA)-ribose system, whereas the aqueous extract had no effect in both BSA-fructose and BSA-ribose systems. The phytochemical profile was investigated with liquid chromatography-ultraviolet-visible (UV-Vis) diode array coupled to electrospray ionization multistage mass spectrometry (LC/DAD/ESI-MSn). Quantification of the major phenolic compounds was performed with high performance liquid chromatography with UV-Vis diode array detection and nuclear magnetic resonance spectroscopy. Among the major phenolic components (luteolin, hydroxytyrosol, luteolin-4′-O-β-D-glucopyranoside, luteolin-7-O-β-D-glucopyranoside, and oleuropein), luteolin and luteolin-4′-O-β-D-glucopyranoside were assigned as potent inhibitors of AGE formation. The extraction procedure greatly affects the composition and therefore the anti-glycation potential of olive leaves.


6 Summary -


7 Article Published Date 2013.


8 Study Type Invitro.


9 Substances Olive leaf.


10 Diseases Diabetes.


11 Pharmacological Actions Antidiabetic/Antiglycation.


12 Link https://goo.gl/MFT1Fe








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