The world's biggest scientific documented health website for the happiness and health of your family, with science and faith we build the balance

107861177

Olive leaf down-regulates the oxidative stress and immune dysregulation in streptozotocin-induced diabetic mice.

Olive leaf down-regulates the oxidative stress and immune dysregulation in streptozotocin-induced diabetic mice.









No. Divisions/Titles for Abstract Details

1 Abstract Title Olive leaf down-regulates the oxidative stress and immune dysregulation in streptozotocin-induced diabetic mice.


2 Abstract Source Nutrition Research, 33, 942-951.


3 Abstract Author(s) Park, J.-H., Jung, J.-H., Yang, J.-Y. & Kim, H.-S.


4 Article Affiliation Division of Biological Science, College of Science, Sookmyung Women's University, Seoul, Korea.


5 Abstract Type 1 diabetes is an endocrinologic disorder characterized by uncontrolled glucose regulation and oxidative stress. Olive leaves have been studied extensively for their antioxidant activity and capacity to improve immune function. We hypothesized that olive leaf powder supplementation will be effective in inhibiting the oxidative stress and immune dysregulation in streptozotocin (STZ)-induced diabetic mice. Mice were assigned to 1 of 5 groups: control (C), STZ-induced diabetes (D), and STZ-induced diabetes supplemented with very low dose (VLOL), low dose (LOL), or high dose of olive leaf powder (HOL). Blood glucose in the VLOL and LOL groups was lower than that in the D group (P < .05). Insulin levels were increased in all experimental groups in comparison with that in the D group, (P < .05). Superoxide dismutase, glutathione peroxidase, and catalase activities were shown to decrease in the D group, whereas these were increased in the VLOL and LOL groups. Nitric oxide levels decreased in the VLOL and LOL groups, as compared with the D group. The messenger RNA expression levels of inducible nitric oxide synthase were significantly decreased in the VLOL and HOL groups, and interferon-γ levels were significantly decreased in the liver of the VLOL, LOL, and HOL groups compared with the levels in the D group. Interleukin-17 levels were significantly decreased in the VLOL and HOL groups. Th1 and Th17 cytokine levels were increased in the D group but decreased in all the experimental groups. Th2 cytokine levels were increased in all olive leaf–supplemented groups compared with those in the D group. These results indicate a reduction in the levels of proinflammatory cytokines, suggesting that olive leaves have the potential to provide therapeutic inhibition of diabetic complications.


6 Summary -


7 Article Published Date
November 2013.


8 Study Type Invivo.


9 Substances Olive leaf.


10 Diseases Diabetes.


11 Pharmacological Actions Antidiabetic.


12 Link https://goo.gl/LxyA3h








videos balancecure


Share it



Subscribe with our newsletter


Comments

No Comments

Add comment

Made with by Tashfier

loading gif
feedback