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Neuroprotective properties of resveratrol in different neurodegenerative disorders.

Neuroprotective properties of resveratrol in different neurodegenerative disorders.










No.Divisions/Titles for AbstractDetails

1Abstract TitleNeuroprotective properties of resveratrol in different neurodegenerative disorders.


2Abstract SourceBiofactors, 36, 370-6.


3Abstract Author(s)Albani, D., Polito, L., Signorini, A. & Forloni, G.


4Article Affiliation
Department of Neuroscience, Mario Negri Institute for Pharmacological Research, Milan, Italy. diego.albani@marionegri.it


5AbstractThe natural phytocompound resveratrol has been considered for many years a potential anticancer drug, but recently it has come to the attention of neuroscientist too, as it displays neuroprotective actions and activates the sirtuins' family member SIRT1. Sirtuins are enzymes with preferential deacetylase activity. Human sirtuins are coded by seven genes (SIRT1-7). The most investigated sirtuin is SIRT1, which is involved in several physiologic and pathologic processes including apoptosis, autophagy, diabetes, cancer, cardiovascular disorders, and neurodegeneration. Resveratrol has neuroprotective features both in vitro and in vivo in models of Alzheimer's disease (AD), but it has proved to be beneficial also in ischemic stroke, Parkinson's disease, Huntington's disease, and epilepsy. Here, we summarize the in vitro and in vivo experimental results highlighting the possible role of resveratrol as neuroprotective biofactor with a particular focus on AD.


6Summarythe in vitro and in vivo experimental results highlighting the possible role of resveratrol as neuroprotective biofactor with a particular focus on ( Alzheimer's disease )AD.


7Article Published Date16 september 2010.


8Study TypeReview.

9SubstancesGrape skin . Resveratrol.


10Diseasesneurodegenerative disorders , Alzheimer's disease (AD), but it has proved to be beneficial also in ischemic stroke, Parkinson's disease, Huntington's disease, and epilepsy.


11Pharmacological Actionsneuroprotective.


12Linkhttps://goo.gl/yHe2Mj








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