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Natural products in treatment of ulcerative colitis and peptic ulcer.

Natural products in treatment of ulcerative colitis and peptic ulcer.


  No. Divisions/Titles for Abstract Details  
  1 Abstract Title  Natural products in treatment of ulcerative colitis and peptic ulcer.
  2 Abstract Source Journal of Saudi Chemical Society, 17, 101-124.
  3 Abstract Author(s) Awaad, A. S., El-Meligy, R. M. & Soliman, G. A. 
  4 Article Affiliation Chemistry Department, Faculty of Science, King Saud University, Riyadh, Saudi Arabia.
  5 Abstract

Ulcerative colitis (a disease that causes inflammation and sores (ulcers) in the lining of the large intestine (colon ). It usually affects the lower section (sigmoid colon) and the rectum. But it can affect the entire colon. In general, the more of the colon that's affected, the worse the symptoms will be.) is an inflammatory chronic disease that affects the mucosa and submucosa of the colon and rectum. Several types of drugs are available such as aminosalicylates.(Aminosalicylate are a class of medications that is often used to treat ulcerative colitis and Crohn's Disease) Peptic ulcer disease (PUD) ( is a break in the lining of the stomach, first part of the small intestine or occasionally the lower esophagus)is a common disorder that affects millions of individuals worldwide and it can be considered one of the most important common diseases in the world. Treatment of peptic ulcers depends on using a number of synthetic drugs that reduce the rate of stomach acid secretion (Antiacids), protect the mucous tissues that line the stomach and upper portion of the small intestine (Demulcents) or to eliminate Helicobacter pylori (H. pylori). In most cases, incidence of relapses and adverse reactions is seen in the following synthetic antiulcer therapy. Accordingly, the main concern of the current article is to introduce a safe drug (or more) of natural origin, to be used for the management of gastric ulcers without side effects.A widespread search has been launched to identify new anti-ulcer therapies from natural sources. Herbs, medicinal plants, spices, vegetables and crude drug substances are considered to be a potential source to control various diseases including gastric ulcer and ulcerative colitis. In the scientific literature, a large number of medicinal plants and their secondary metabolites with potential anti-ulcer (anti-peptic ulcer and antiulcerative colitis) activities have been reported. Treatment with natural products produces promising results and fewer side effects. Our goal is to collect the published data in the last 24 years and reviews the natural products reported in the treatment of these diseases and their mechanism of action.

  6 Summary Flavonoids are important for the normal growth, development and defense of plants. Flavonoids possess both cytoprotective and antisecratory activities. They exerts a gastroprotective action in mammals by increasing endogenous prostaglandin levels, decreasing histamine secreation, inhibiting Helicobacter pylori and scavenging oxygen derived free radicals. The antisecratory mechanism includes the antioxidant property . In similar study, other workers concluded that, wheat grass (Triticum aestivum L., Poaceae) juice appeared effective and safe as a single or adjuvant treatment of active distal Ulcerative colitis.
  7 Article Published Date March 2012.  
  8 Study Type Review.  
  9 Substances Wheat grass.  
  10 Diseases IBS.  
  11 Pharmacological Actions Treatment of IBS.  
  12 Link


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