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Manuka honey-impregnated dressings in the treatment ofneuropathic diabetic foot ulcers.

Manuka honey-impregnated dressings in the treatment ofneuropathic diabetic foot ulcers.









No. Divisions/Titles for Abstract Details

1 Abstract Title Manuka honey-impregnated dressings in the treatment ofneuropathic diabetic foot ulcers.


2 Abstract Source  International wound journal, 11, 259-263.


3 Abstract Author(s) Kamaratos, A. V., Tzirogiannis, K. N., Iraklianou, S. A., Panoutsopoulos, G. I., Kanellos, I. E. & Melidonis, A. I.


4 Article Affiliation Diabetes Center, Tzanio General Hospital, Piraeus, Greece.


5 Abstract In this study, we investigate the effect of manuka honey-(Manuka honey is produced in New Zealand by bees that pollinate the native manuka bush)impregnated (soak or saturate (something) with a substance)dressings(MHID) on the healing of neuropathic diabetic foot ulcers (NDFU)(Neuropathic ulcers form as a result of peripheral neuropathy, typically in diabetic patients. Local paresthesias, or lack of sensation, over pressure points on the foot leads to extended microtrauma, breakdown of overlying tissue, and eventual ulceration. In addition, neuropathy can result in minor scrapes or cuts failing to be properly treated and eventually developing into ulcers.). A total of 63 Caucasians (grouping of human beings historically regarded as a biological taxon, which, depending on which of the historical race classifications used, have usually included some or all of the ancient and modern populations of Europe, the Caucasus, Asia Minor, North Africa), type 2 diabetic patients followed up in the diabetic foot outpatient clinic comprised the study population. Patients were randomised in two groups as follows:group I patients were treated with MHID and group II patients were treated withconventional dressings (CD). The patients were followed up on a weekly basis for 16weeks. Mean healing time was 31 ± 4 days in group I versus 43 ± 3 days in group II(P<0·05). In group I patients 78·13% of ulcers became sterile during the first weekversus 35·5% in group II patients; the corresponding percentages for weeks 2, 4 and 6were 15·62% versus 38·7%, 6·25% versus 12·9% and 0% versus 12·9% respectively.The percent of ulcers healed did not differ significantly between groups (97% forMHID and 90% for CD). MHID represent an effective treatment for NDFU leading to a significant reduction in the time of healing and rapid disinfection (the process of cleaning something, especially with a chemical, in order to destroy bacteria.)of ulcers.


6 Summary Methylglyoxal, the active antibacterial ingredient of Manuka honey. has been reported to react with lysine, arginine and cys-teine residues of structural proteins, such as collagen, givinggenesis to advanced glycation end products (AGEs) thatdisrupt extracellular matrix remodeling, promote fibrosis inchronic tissue infections, impair immune response and micro-circulation, promote a therosclerosis and neovascularisation induce endothelial cell dysfunction and impair wound clo-sure.The above have raised concerns about a possibledetrimental effect of methyglyoxal, and consequently MH, inthe healing of diabetic foot ulcers


7 Article Published Date 2014.


8 Study Type Clinical.


9 Substances Manuka honey.


10 Diseases Diabetic foot ulcer.


11 Pharmacological Actions Healing effect for diabetic foot ulcer.


12 Link https://goo.gl/GNok6e








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