Lipid-lowering and antioxidant effects of hydroxytyrosol and its triacetylated derivative recovered from olive tree leaves in cholesterol-fed rats.


No.	Divisions/Titles for Abstract	Details
1	Abstract Title	Lipid-lowering and antioxidant effects of hydroxytyrosol and its triacetylated derivative recovered from olive tree leaves in cholesterol-fed rats.
2	Abstract Source	Journal of Agricultural and Food Chemistry, 56, 2630-2636.
3	Abstract Author(s)	Jemai, H., Fki, I., Bouaziz, M., Bouallagui, Z., El Feki, A., Isoda, H. & Sayadi, S.
4	Article Affiliation	Laboratoire des Bioprocédés, Pôle d’Excellence Régional AUF, Centre de Biotechnologie de Sfax, B.P. «K» 3038 Sfax, Tunisia.
5	Abstract	This study was designed to test the lipid-lowering and antioxidative activities of triacetylated hydroxytyrosol compared with its native compound, hydroxytyrosol, purified from olive tree leaves. Wistar rats fed a standard laboratory diet or a cholesterol-rich diet for 16 weeks were used. The serum lipid levels, the thiobarbituric acid-reactive substances (TBARS) level, as an indicator of lipid peroxidation, and the activity of superoxide dismutase (SOD) as well as that of catalase (CAT) were examined. The cholesterol-rich diet induced hypercholesterolemia that was manifested in the elevation of total cholesterol (TC), triglycerides (TG), and low-density lipoprotein cholesterol (LDL-C). Administration of hydroxytyrosol and triacetylated hydroxytyrosol (3 mg/kg of body weight) decreased the serum levels of TC, TG, and LDL-C significantly and increased the serum level of high-density lipoprotein cholesterol (HDL-C). Furthermore, the content of TBARS in liver, heart, kidney, and aorta decreased significantly when hydroxytyrosol and its triacetylated derivatives were orally administered to rats compared with those fed a cholesterol-rich diet. In addition, triacetylated hydroxytyrosol and hydroxytyrosol increased CAT and SOD activities in the liver. These results suggested that the hypolipidemic effect of triacetylated hydroxytyrosol and hydroxytyrosol might be due to their abilities to lower serum TC, TG, and LDL-C levels as well as to their antioxidant activities preventing the lipid peroxidation process.
6	Summary	-
7	Article Published Date	2008.
8	Study Type	Invivo.
9	Substances	Olive leaf.
10	Diseases	Hypercholesterolemia.
11	Pharmacological Actions	Antioxidant & reduce cholesterol level.
12	Link	https://goo.gl/a3C8TS