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Levels of S100B protein are higher in mature human milk than in colostrum and milk-formulae milks.

Levels of S100B protein are higher in mature human milk than in colostrum and milk-formulae milks.









No. Divisions/Titles for Abstract Details

1 Abstract Title Levels of S100B protein are higher in mature human milk than in colostrum and milk-formulae milks.


2 Abstract Source Clinical Nutrition, 23, 23-26.


3 Abstract Author(s) Gazzolo, D., Bruschettini, M., Lituania, M., Serra, G., Santini, P. & Michetti, F.


4 Article Affiliation a Department of Obstetrics and Pediatrics, Giannina Gaslini Children's University Hospital, I-16147 Genoa, Italy
b Institute of Anatomy, Catholic University, I-00168 Rome, Italy.


5 Abstract Background & Aims: Human milk is believed to contain biological factors involved in the regulation of newborn growth, including brain development. Recently, it has also been shown to contain the calcium-binding S100B protein, regarded as a neurotrophic factor. The present study investigates the concentrations of this protein in colostrum, human milk at different levels of maturation and in milk-formulae.
Methods: Samples for S100B measurements were collected from human colostrum (on day 1 after birth), from transition milk (on post-delivery days 7 and 14) and from mature milk (on day 30 after delivery) in 14 healthy women and from 14 milk-formulae. The S100B protein levels were measured using a commercially available specific immunoluminometric assay.
Results: Mean S100B protein levels were significantly higher in mature human milk (117.9±36.7 μg/l) than in transition milk at 14 days (106.7±38.1 μg/l) and at 7 days (92.7±37.8 μg/l), colostrum (74.6±37.6 μg/l) or milk-formulae (24.8±19.5 μg/l) (P<0.001, for all). A correlation between human milk S100B levels and the gestational age at which samples were obtained was also found (r=0.39; P<0.01).
Conclusions: These findings, possibly related to S100B's neurotrophic role, offers useful information to the investigation of the role of S100B protein in brain maturation.


6 Summary Mean S100B protein levels were significantly higher in mature human milk .  A correlation between human milk S100B levels and the gestational age at which samples were obtained was also found (r=0.39; P<0.01).These findings, possibly related to S100B's neurotrophic role, offers useful information to the investigation of the role of S100B protein in brain maturation.


7 Article Published Date Feb 2004.


8 Study Type clinical.


9 Substances Colostrum.


10 Diseases Levels of S100B protein ( S100B's neurotrophic factor & brain maturation ).


11 Pharmacological Actions S100B's neurotrophic factor & brain maturation.


12 Link https://goo.gl/hPj8xo








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