• الأردن: 00962781409934 - 00962778455550 - 00962791066457, الإمارات: 00971564999475 - 00971501299947 - 00971564880709
  • الجزائر: 0549996833, تونس: 0021695451643, بريطانيا و أوروبا: 00441902871854 - 00447519398225 - 00447517362128 - 00447519398239
  • تركيا: 00905539440472, أمريكا و كندا: 0017735728151 - 0017736162627 - 0018472850055
  • العراق: 07733000696 - 07733598900

The world's biggest scientific documented health website for the happiness and health of your family, with science and faith we build the balance

97935038

Intravenous Administration of Manuka Honey Inhibits Tumor Growth and Improves Host Survival When Used in Combination with Chemotherapy in a Melanoma Mouse Model.

Intravenous Administration of Manuka Honey Inhibits Tumor Growth and Improves Host Survival When Used in Combination with Chemotherapy in a Melanoma Mouse Model.









No. Divisions/Titles for Abstract Details

1 Abstract Title Intravenous Administration of Manuka Honey Inhibits Tumor Growth and Improves Host Survival When Used in Combination with Chemotherapy in a Melanoma Mouse Model.


2 Abstract Source PLoS One, 8, e55993.


3 Abstract Author(s) Fernandez-Cabezudo, M. J., El-Kharrag, R., Torab, F., Bashir, G., George, J. A., El-Taji, H. & Al-Ramadi, B. K.


4 Article Affiliation Department of Medical Microbiology & Immunology, College of Medicine and Health Sciences, UAE University, Al Ain, United Arab Emirates.


5 Abstract Manuka honey ( a monofloral honey produced in Australia and New Zealand from the nectar of the mānuka tree)has been recognized for its anti-bacterial (to kill or eradicate bacteria) and wound-healing activity but its potential antitumor (preventing or inhibiting the formation or growth of tumors)effect is poorly studied despite the fact that it contains many antioxidant (a substance that inhibits oxidation, especially one used to counteract the deterioration of stored food products)compounds. In this study, we investigated the antiproliferative (relating to a substance used to prevent or retard the spread of cells, especially malignant cells, into surrounding tissues) activity of manuka honey on three different cancer cell lines, murine melanoma (a type of cancer that develops from the pigment-containing cells known as melanocytes)(B16.F1) and colorectal carcinoma (also known as bowel cancer and colon cancer, is the development of cancer from the colon or rectum )(CT26) as well as human breast cancer (MCF-7) cells in vitro. The data demonstrate that manuka honey has potent anti-proliferative effect on all three cancer cell lines in a time- and dose-dependent manner, being effective at concentrations as low as 0.6% (w/v). This effect is mediated via the activation of a caspase 9-dependent ( an initiator caspase, encoded by the CASP9 gene)apoptotic (a process of programmed cell death that occurs in multicellular organisms)pathway, leading to the induction of caspase 3, reduced Bcl-2 expression (encoded in humans by the BCL2 gene, is the founding member of the Bcl-2 family of regulator proteins that regulate cell death (apoptosis), by either inducing (pro-apoptotic) or inhibiting (anti-apoptotic) apoptosis), DNA fragmentation (he separation or breaking of DNA strands into pieces. It can be done intentionally by laboratory personnel or by cells, or can occur spontaneously)and cell death. Combination treatment of cancer cells with manuka and paclitaxel (chemotherapy medication used to treat a number of types of cancer)in vitro(inside laboratory), however, revealed no evidence of a synergistic (relating to the interaction or cooperation of two or more organizations, substances, or other agents to produce a combined effect greater than the sum of their separate effects.)action on cancer cell proliferation (rapid increase in the number or amount of something). Furthermore, we utilized an in vivo syngeneic mouse melanoma model to assess the potential effect of intravenously-administered manuka honey, alone or in combination with paclitaxel, on the growth of established tumors. Our findings indicate that systemic administration of manuka honey was not associated with any alterations in haematological (branch of medicine concerned with the study of the cause, diagnosis, treatment, and prevention of diseases related to blood)or clinical chemistry values in serum of treated mice, demonstrating its safety profile. Treatment with manuka honey alone resulted in about 33% inhibition of tumor growth, which correlated with histologically observable increase in tumor apoptosis. Although better control of tumor growth was observed in animals treated with paclitaxel alone or in combination with manuka honey (61% inhibition), a dramatic improvement in host survival was seen in the co-treatment group. This highlights a potentially novel role for manuka honey in alleviating chemotherapy-induced toxicity.


6 Summary The main mechanism by which manuka appears to exert its anti-proliferative effect on cancer cells is through the activation of the intrinsic apoptotic pathway, involving the induction of the initiator caspase-9 which in turns activates the executioner caspase-3.


7 Article Published Date 2013.


8 Study Type Invitro.


9 Substances Manuka honey.


10 Diseases Cancer.


11 Pharmacological Actions anti-cancer.


12 Link https://goo.gl/kkvgQj








videos balancecure


Share it



Subscribe with our newsletter


Comments

No Comments

Add comment

Made with by Tashfier

loading gif
feedback