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Inhibitory Effects of Grape Seed Extract on Lipases.

Inhibitory Effects of Grape Seed Extract on Lipases.

No. Divisions/Titles for Abstract Details

1 Abstract Title
Inhibitory Effects of Grape Seed Extract on Lipases.

2 Abstract Source
Nutrition, 19, 876-879.

3 Abstract Author(s)
Moreno, D. A., Ilic, N., Poulev, A., Brasaemle, D. L., Fried, S. K. & Raskin, I.

4 Article Affiliation
Biotech Center and the Department of Nutritional Sciences, Cook College, Rutgers— The State University of New Jersey, New Brunswick, New Jersey, USA.

5 Abstract OBJECTIVE: The aim of the present study was to assess the effects of grape seed extract (GSE) on the fat-metabolizing enzymes pancreatic lipase, lipoprotein lipase, and hormone-sensitive lipase in vitro and evaluate its potential application as a treatment for obesity. METHODS: Crushed grape seeds were extracted in ethanol, and the extract was assayed for the measurement of inhibitory effects on pancreatic lipase and lipoprotein lipase activities and on lipolysis of 3T3-L1 adipocytes. RESULTS: The GSE rich in bioactive phytochemicals showed inhibitory activity on the fat-metabolizing enzymes pancreatic lipase and lipoprotein lipase, thus suggesting that GSE might be useful as a treatment to limit dietary fat absorption and the accumulation of fat in adipose tissue. The observed reduction in intracellular lipolytic activity of cultured 3T3-L1 adipocytes may reduce the levels of circulating free fatty acids that have been linked to insulin resistance in obese patients. CONCLUSION: The GSE rich in compounds that inhibit lipases may provide a safe, natural, and cost effective weight control treatment.

6 Summary -

7 Article Published Date October 2003.

8 Study Type Invitro.

9 Substances Grape seed.

10 Diseases Obesity.

11 Pharmacological Actions Lipase inhibition.Antiobesity.

12 Link

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