Grape seed extract (Vitis vinifera) partially reverses high fat diet-induced obesity in C57BL/6J mice.


No.	Divisions/Titles for Abstract	Details
1	Abstract Title	Grape seed extract (Vitis vinifera) partially reverses high fat diet-induced obesity in C57BL/6J mice.
2	Abstract Source	Nutrition Research and Practice, 2, 227-233.
3	Abstract Author(s)	Park, S.-H., Park, T.-S. & Cha, Y.-S.
4	Article Affiliation	1Department of Food Science and Human Nutrition, Research Institute of Human Ecology, Chonbuk National University, 664-14 1Ga Deokjin-dong, Deokjin-gu, Jeonju, Jeonbuk 561-756, Korea. 2Division of Endocrinology and Metabolism, Department of Internal Medicine, Chonbuk National University, 664-14 1Ga Deokjin-dong, Deokjin-gu, Jeonju, Jeonbuk 561-756, Korea.
5	Abstract	The aim of the present study was to assess the anti-obesity effects of grape seed extract (GSE) supplement in C57BL/6J mice. Thirty mice were divided into three groups; normal diet control group (ND), high fat diet control group (HD) and high fat diet plus grape seed extract supplemented group (HD+GSE). Results were as follows: 1. GSE supplement reduced the weight gain in mice fed high fat diets; epididymal and back fat weights were lower compared to non-supplemented HD group. 2. Blood lipid concentrations were lower in the HD+GSE group than in the HD group. Serum HDL-C concentrations were higher in the HD+GSE group compared with the other groups. 3. The concentrations of acid-insoluble acylcarnitines (AIAC) in serum and liver were higher in the HD+GSE group than in the HD group. 4. GSE supplementation increased mRNA levels of lipolytic genes such as carnitine palmitoyltransferase-1 (CPT-1) and decreased mRNA levels of lipogenic genes such as acetyl CoA carboxylase (ACC). These findings suggest that grape seed extract supplements in high fat diet might normalize body weight, epididymal and back fat weights, lipid concentrations, and carnitine levels through controlling lipid metabolism.
6	Summary	-
7	Article Published Date	2008.
8	Study Type	Invitro.
9	Substances	Grape seed.
10	Diseases	Obesity.
11	Pharmacological Actions	Treatment of Obesity.
12	Link	https://goo.gl/pjcNK1