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Experimental evidence for the cardioprotective effects of red wine.

Experimental evidence for the cardioprotective effects of red wine.

No.Divisions/Titles for AbstractDetails

1Abstract TitleExperimental evidence for the cardioprotective effects of red wine.

2Abstract SourceExperimental & Clinical Cardiology, 12, 5-10.

3Abstract Author(s)Das, S., Santani, D. D. & Dhalla, N. S.

4Article AffiliationInstitute of Cardiovascular Sciences, St Boniface General Hospital Research Centre, Department of Physiology, Faculty of Medicine, University of Manitoba, Winnipeg, Canada.

5AbstractBoth epidemiological and experimental studies have revealed that intake of wine, particularly red wine, in moderation protects cardiovascular health; however, the experimental basis for such an action is not fully understood. Because all types of red wine contain varying amounts of alcohol and antioxidants, it is likely that the cardioprotective effect of red wine is due to both these constituents. In view of its direct action on the vascular smooth muscle cells, alcohol may produce coronary vasodilation in addition to attenuating oxidative stress by its action on the central nervous system. The antioxidant components of red wine may provide cardioprotection by their ability to reduce oxidative stress in the heart under different pathological conditions. Mild-to-moderate red wine consumption improves cardiac function in the ischemic myocardium through the protection of endothelial function, the expression of several cardioprotective oxidative stress-inducible proteins, as well as the activation of adenosine receptors and nitrous oxide synthase mechanisms.

6SummaryRed wine attenuates ischemia and/or reperfusion injury; thus, it produces cardioprotection. Components of red wine, such as alcohol and polyphenolic compounds (such as resveratrol and proanthocyanidin), serve equally for its cardioprotective property but through two different mechanisms. Polyphenolic antioxidants scavenge the free radicals while alcohol protects from cellular injury by adapting the heart to oxidative stress. The overall effect of these two components of red wine makes red wine a potent therapeutic agent for the amelioration of myocardial injury associated with ischemia-reperfusion.

7Article Published Date2007.

8Study TypeReview.

9SubstancesGrape skin.

10Diseasesmyocardial ichemia ,oxidative stress.

11Pharmacological Actionscardioprotective , antioxident.


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