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Dry olive leaf extract ameliorates experimental autoimmune encephalomyelitis.

Dry olive leaf extract ameliorates experimental autoimmune encephalomyelitis.









No. Divisions/Titles for Abstract Details

1 Abstract Title Dry olive leaf extract ameliorates experimental autoimmune encephalomyelitis.


2 Abstract Source Clinical Nutrition, 28, 346-350.


3 Abstract Author(s) Miljković, D., Dekanski, D., Miljković, Ž., Momčilović, M. & Mostarica-Stojkovic, M.


4 Article Affiliation Institute for Biological Research “Siniša Stanković”, Department of Immunology, University of Belgrade, Belgrade, Serbia.


5 Abstract Background & aims
Experimental autoimmune encephalomyelitis (EAE) is an animal model of CNS inflammatory and demyelinating disease multiple sclerosis. Mediterranean diet, rich in olive products is associated with lower incidence of multiple sclerosis in South European population. Therefore, the influence of dry olive leaf extract (DOLE) on EAE course was investigated.

Methods
Spinal cord homogenate and complete Freund's adjuvant were used for the induction of EAE in Dark Agouti rats. DOLE was applied intragastrically once per day, starting from the day of the immunization. Real time PCR and ELISA were used for the determination of IFN-γ and IL-17 gene expression and production, respectively.

Results
DOLE reduced various parameters of EAE severity in DA rats, including cumulative disease index, maximal clinical score and disease duration. Also, DOLE decreased cellularity of the draining lymph nodes and production of IFN-γ and IL-17 by the cells infiltrating spinal cord of EAE rats.

Conclusions
The results presented in this paper strongly suggest that DOLE-enriched diet has a beneficial effect in EAE in rats. Further studies in humans are required in order to investigate if DOLE could be a useful supplementary dietetic for the patients suffering from multiple sclerosis and other neuroinflammatory disorders.


6 Summary -


7 Article Published Date
June 2009.


8 Study Type Invivo.


9 Substances Olive leaf.


10 Diseases Encephalomyelitis.


11 Pharmacological Actions Antiinflammatory.


12 Link https://goo.gl/aAghtD








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