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Dietary Supplementation of Grape Skin Extract Improves Glycemia and Inflammation in Diet-Induced Obese Mice Fed a Western High Fat Diet.

Dietary Supplementation of Grape Skin Extract Improves Glycemia and Inflammation in Diet-Induced Obese Mice Fed a Western High Fat Diet.










No.Divisions/Titles for AbstractDetails

1Abstract TitleDietary Supplementation of Grape Skin Extract Improves Glycemia and Inflammation in Diet-Induced Obese Mice Fed a Western High Fat Diet.


2Abstract SourceJournal of agricultural and food chemistry, 59, 3035-3041.


3Abstract Author(s)Hogan, S., Canning, C., Sun, S., Sun, X., Kadouh, H. & Zhou, K. 


4Article Affiliation

† Department of Food Science and Technology, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061, United States

§ Department of Nutrition and Food Science, Wayne State University, Detroit, Michigan 48202, United States

‡ Montana State University, Bozeman, Montana 59717.



5AbstractDietary antioxidants may provide a cost-effective strategy to promote health in obesity by targeting oxidative stress and inflammation. We recently found that the antioxidant-rich grape skin extract (GSE) also exerts a novel anti-hyperglycemic activity. This study investigated whether 3-month GSE supplementation can improve oxidative stress, inflammation, and hyperglycemia associated with a Western diet-induced obesity. Young diet-induced obese (DIO) mice were randomly divided to three treatment groups (n = 12): a standard diet (S group), a Western high fat diet (W group), and the Western diet plus GSE (2.4 g GSE/kg diet, WGSE group). By week 12, DIO mice in the WGSE group gained significantly more weight (24.6 g) than the W (20.2 g) and S groups (11.2 g); the high fat diet groups gained 80% more weight than the standard diet group. Eight of 12 mice in the W group, compared to only 1 of 12 mice in the WGSE group, had fasting blood glucose levels above 140 mg/dL. Mice in the WGSE group also had 21% lower fasting blood glucose and 17.1% lower C-reactive protein levels than mice in the W group (P < 0.05). However, the GSE supplementation did not affect oxidative stress in diet-induced obesity as determined by plasma oxygen radical absorbance capacity, glutathione peroxidase, and liver lipid peroxidation. Collectively, the results indicated a beneficial role of GSE supplementation for improving glycemic control and inflammation in diet-induced obesity.


6Summarythe results of this study  indicated a beneficial role of GSE supplementation for improving glycemic control and inflammation in diet-induced obesity.


7Article Published Date2011.

8Study TypeInvivo.

9SubstancesGrape skin.

10Diseasesinflammation  , oxidative stress.


11Pharmacological Actions anti-hyperglycemic , antiinflammatory , antioxidant.


12Linkhttps://goo.gl/trJ4XW








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