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Antioxidant, Anti-inflammatory, and Antiulcer Potential of Manuka Honey against Gastric Ulcer in Rats.

Antioxidant, Anti-inflammatory, and Antiulcer Potential of Manuka Honey against Gastric Ulcer in Rats.









No. Divisions/Titles for Abstract Details

1 Abstract Title Antioxidant, Anti-inflammatory, and Antiulcer Potential of Manuka Honey against Gastric Ulcer in Rats.


2 Abstract Source Oxidative Medicine and Cellular Longevity, 2016, 3643824.


3 Abstract Author(s) Almasaudi, S. B., El-Shitany, N. A., Abbas, A. T., Abdel-Dayem, U. A., Ali, S. S., Al Jaouni, S. K. & Harakeh, S.


4 Article Affiliation Biology Department, Faculty of Science, King Abdulaziz University, Jeddah 21589, Saudi Arabia.


5 Abstract Gastric ulcers (ulcer that occur on the inside of the stomach)are among the most common diseases affecting humans. This study aimed at investigating the gastroprotective effects of manuka honey (Manuka honey is produced in New Zealand by bees that pollinate the native manuka bush. Advocates say it treats wound infections and other conditions)against ethanol-induced gastric ulcers in rats. The mechanism by which honey exerts its antiulcer potential was elucidated. Four groups of rats were used: control, ethanol (ulcer), omeprazole, and manuka honey. Stomachs were examined macroscopically for hemorrhagic (condition caused by a rupture in a weakened blood vessel )lesions in the glandular mucosa, ((The gastroesophageal junction is the anatomic junction of the saccular stomach with the tubular esophagus. The squamo-columnar junction is where the glandular mucosa meets the squamous mucosa))histopathological changes, and glycoprotein (any of a class of proteins which have carbohydrate groups attached to the polypeptide chain)detection. The effects of oxidative stress were investigated using the following indicators: gastric mucosal nitric oxide (NO), reduced glutathione (GSH), lipid peroxide (MDA, measured as malondialdehyde) glutathione peroxidase (GPx), superoxide dismutase (SOD), and catalase. Plasma tumour necrosis factor-α, interleukin-1β, and IL-6 ((inflammatory cytokine is a type of signaling molecule (a cytokine) that is excreted from immune cells like helper T cells (Th) and macrophages, and certain other cell types that promote inflammation.)were also measured. Manuka honey significantly decreased the ulcer index, completely protected the mucosa from lesions, and preserved gastric mucosal glycoprotein. It significantly increased gastric mucosal levels of NO, GSH, GPx, and SOD. Manuka honey also decreased gastric mucosal MDA and plasma TNF-α, IL-1β, and IL-6 concentrations. In conclusion, manuka honey likely exerted its antiulcer, effect by keeping enzymatic (GPx and SOD) and nonenzymatic (GSH and NO) antioxidants as well as inflammatory cytokines (TNF-α, IL-1β, and IL-6) in a reduced form, inhibited lipid peroxidation (MDA), and preserved mucous glycoproteins levels.


6 Summary Manuka honey significantly decreased the ulcer index, completely protected the mucosa from lesions, and preserved gastric mucosal glycoprotein. It significantly increased gastric mucosal levels of NO, GSH, GPx, and SOD. Manuka honey also decreased gastric mucosal MDA and plasma TNF-α, IL-1β, and IL-6 concentrations. In conclusion, manuka honey likely exerted its antiulcer, effect by keeping enzymatic (GPx and SOD) and nonenzymatic (GSH and NO) antioxidants as well as inflammatory cytokines (TNF-α, IL-1β, and IL-6) in a reduced form, inhibited lipid peroxidation (MDA), and preserved mucous glycoproteins levels.


7 Article Published Date 07/12/2015.


8 Study Type Invivo.


9 Substances Manuka honey.


10 Diseases
Gastric ulcer.


11 Pharmacological Actions anti-ulcer.


12 Link https://goo.gl/qe37KK








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