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Anticancer activity of lactoferrin isolated from caprine colostrum on human cancer cell lines.

Anticancer activity of lactoferrin isolated from caprine colostrum on human cancer cell lines.









No. Divisions/Titles for Abstract Details

1 Abstract Title Anticancer activity of lactoferrin isolated from caprine colostrum on human cancer cell lines.


2 Abstract Source International Journal of Dairy Technology, 62, 277-281.


3 Abstract Author(s) Kim, Y., Kim, M. J., Han, K. S., Imm, J. Y., Oh, S. & Kim, S. H.


4 Article Affiliation Division of Food Bioscience and Technology, College of Life Science and Biotechnology, Korea University, Seoul 136-701, South Korea.


5 Abstract In the present study, lactoferrin was purified from caprine colostrum and its anticancer effects were investigated on various cancer cell lines, including lung, colon, cervix, stomach and breast cancer cells. The caprine lactoferrin (CLF) was purified by ultrafiltration and sequential chromatography using a CM-Sephadex C-50-120 ion-exchange column and affinity chromatography on Hi-TrapTM Heparin HP. The purified CLF exhibited antiproliferative effects on the five tested cancer cell lines in a dose-dependent manner, with 20-30% survival as compared to the control. Interestingly, the most intense inhibition of cell growth was observed on the ZR-75-1 breast cancer cells (IC50 = 27.5 μg/mL). Our findings suggest, for the first time, that purified CLF from caprine colostrum may constitute a novel anticancer agent for the food industry.


6 Summary Lactoferrin was purified from caprine colostrum and its anticancer effects were investigated on various cancer cell lines, including lung, colon, cervix, stomach and breast cancer cells. The most intense inhibition of cell growth was observed on the ZR-75-1 breast cancer cell.


7 Article Published Date
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8 Study Type Invitro.


9 Substances lactoferrin from caprine colostrum .


10 Diseases Cancers including lung, colon, cervix, stomach and breast cancer cells.


11 Pharmacological Actions Anticancer.


12 Link https://goo.gl/PBGYCV








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