• الأردن: 0096278140993 - 00962790633919, الإمارات: 00971564999475 - 00971501299947 - 00971564880709
  • الجزائر: 0549996833, تونس: 0021671805607, بريطانيا: 00447517362128 - 00447519398225 - 00447519398239
  • تركيا: 0095539440472, أمريكا: 0017736162627 - 0017735728151 - 0018472850055

The world's biggest scientific documented health website for the happiness and health of your family, with science and faith we build the balance

93978711

(-)-Carvone: antispasmodic effect and mode of action.

(-)-Carvone: antispasmodic effect and mode of action.










No.Divisions/Titles for AbstractDetails

1Abstract Title(-)-Carvone: antispasmodic effect and mode of action.


2Abstract SourceFitoterapia, 85, 20-4.


3Abstract Author(s)Souza, F. V., Da Rocha, M. B., De Souza, D. P. & Marcal, R. M.


4Article AffiliationPhysiology Department, Federal University of Sergipe, São Cristóvão, Sergipe, Brazil.


5Abstract(-)-Carvone (Carvone is a member of a family of chemicals called terpenoids. Carvone is found naturally in many essential oils, but is most abundant in the oils from seeds of caraway, spearmint, and dill)is a monoterpene ketone ( an organic compound with the structure RC(=O)R', where R and R' can be a variety of carbon-containing substituents. Ketones and aldehydes are simple compounds that contain a carbonyl group (a carbon-oxygen double bond)) found in spearmint (Mentha spicata var. crispa) essential oil that is widely used as an odor and flavor additive. An intestinal antispasmodic (An antispasmodic (synonym: spasmolytic) is a pharmaceutical drug or other agent that suppresses muscle spasms) effect was recently reported for (-)-carvone, and it has been shown to be more potent than its (+)-antipode (the direct opposite of something.). The mechanism of (-)-carvone action in the intestines has not been investigated. To gain a better understanding of the (-)-carvone antispasmodic effect, we investigated its pharmacological effects in the guinea pig ileum (The ileum is about 3.5 metres (11.5 feet) long (or about three-fifths the length of the small intestine) and extends from the jejunum (the middle section of the small intestine) to the ileocecal valve, which empties into the colon (large intestine).). Terminal portions of the ileum were mounted for isotonic contraction recordings. The effect of (-)-carvone was compared with that of the classical calcium channel blocker (CCB) (Calcium channel blockers, calcium channel antagonists or calcium antagonists are several medications that disrupt the movement of calcium through calcium channels)verapamil. In isolated ileal smooth muscle, (-)-carvone did not produce direct contractile or relaxation responses and did not modify electrically elicited contractions or low K(+)-evoked contractions. The submaximal contractions induced by histamine(Histamine - a chemical found in some of the body's cells - causes many of the symptoms of allergies, such as a runny nose or sneezing. When a person is allergic to a particular substance, such as a food or dust, the immune system mistakenly believes that this usually harmless substance is actually harmful to the body.) (p<0.001), BaCl2 (p<0.05), and carbachol (p<0.01) were significantly reduced by (-)-carvone. The contractile response elicited by high concentrations of carbachol was reduced but not abolished by (-)-carvone. No additive action was detected with co-incubation of (-)-carvone and verapamil on carbachol-induced contraction. (-)-Carvone reduced the contraction induced by high K(+) and was almost 100 times more potent than verapamil. Thus, (-)-carvone showed a typical and potent CCB-like action. Many effects described for both (-)-carvone and spearmint oil can be explained as a CCB-like mode of action.


6Summary(-)-Carvone is a monoterpene ketone found in spearmint (Mentha spicata var. crispa) essential oil that is widely used as an odor and flavor additive. An intestinal antispasmodic effect was recently reported for (-)-carvone, and it has been shown to be more potent than its (+)-antipode. The mechanism of (-)-carvone action in the intestines has not been investigated. To gain a better understanding of the (-)-carvone antispasmodic effect, we investigated its pharmacological effects in the guinea pig ileum. Terminal portions of the ileum were mounted for isotonic contraction recordings. The effect of (-)-carvone was compared with that of the classical calcium channel blocker (CCB) verapamil. In isolated ileal smooth muscle, (-)-carvone did not produce direct contractile or relaxation responses and did not modify electrically elicited contractions or low K(+)-evoked contractions. The submaximal contractions induced by histamine (p<0.001), BaCl2 (p<0.05), and carbachol (p<0.01) were significantly reduced by (-)-carvone. The contractile response elicited by high concentrations of carbachol was reduced but not abolished by (-)-carvone. No additive action was detected with co-incubation of (-)-carvone and verapamil on carbachol-induced contraction. (-)-Carvone reduced the contraction induced by high K(+) and was almost 100 times more potent than verapamil. Thus, (-)-carvone showed a typical and potent CCB-like action. Many effects described for both (-)-carvone and spearmint oil can be explained as a CCB-like mode of action.


7Article Published DateMarch 2013.

8Study TypeInvitro.

9SubstancesMint.

10DiseasesIBS.

11Pharmacological ActionsTreatment of IBS.

12Linkhttps://goo.gl/5tPivX








videos balancecure


Share it



Subscribe with our newsletter


Comments

No Comments

Add comment

Made with by Tashfier

loading gif
feedback